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phospho-p-T,Y-MAPK8 [nucleoplasm]
Stable Identifier
R-RNO-216349
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
P49185
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular Senescence (Rattus norvegicus)
Oxidative Stress Induced Senescence (Rattus norvegicus)
Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
DNA Repair (Rattus norvegicus)
DNA Double-Strand Break Repair (Rattus norvegicus)
DNA Double Strand Break Response (Rattus norvegicus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Rattus norvegicus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Rattus norvegicus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-17 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
Activation of the AP-1 family of transcription factors (Rattus norvegicus)
Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated MAPK activation (Rattus norvegicus)
Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
Activation of the AP-1 family of transcription factors (Rattus norvegicus)
Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
Activation of the AP-1 family of transcription factors (Rattus norvegicus)
Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
Activation of the AP-1 family of transcription factors (Rattus norvegicus)
Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
Activation of the AP-1 family of transcription factors (Rattus norvegicus)
Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
Activation of the AP-1 family of transcription factors (Rattus norvegicus)
Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
Activation of the AP-1 family of transcription factors (Rattus norvegicus)
Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
Activation of the AP-1 family of transcription factors (Rattus norvegicus)
Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
Activation of the AP-1 family of transcription factors (Rattus norvegicus)
Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
Activation of the AP-1 family of transcription factors (Rattus norvegicus)
Activated JNKs phosphorylate c-JUN (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Rattus norvegicus)
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
Cell death signalling via NRAGE, NRIF and NADE (Rattus norvegicus)
NRAGE signals death through JNK (Rattus norvegicus)
Active JNK moves to the nucleus and phosphorylates different transcription factors (Rattus norvegicus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P49185 Mapk8
Gene Names
Mapk8, Jnk1, Prkm8
Chain
chain:1-411
Reference Genes
BioGPS Gene:116554 Mapk8
KEGG Gene (Rattus norvegicus):116554 Mapk8
Monarch:116554 Mapk8
NCBI Gene:116554 Mapk8
UCSC:P49185 Mapk8
Reference Transcript
RefSeq:NM_053829.2 Mapk8
Participates
as an input of
APBB1 and MAPK8 bind diphosphorylated H2AFX (Rattus norvegicus)
as a component of
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Rattus norvegicus)
as an output of
Active JNK moves to the nucleus and phosphorylates different transcription factors (Rattus norvegicus)
as a member of
p-MAPK8,9,10 [nucleoplasm] (Rattus norvegicus)
Other forms of this molecule
JNK1 [nucleoplasm]
JNK1 [cytosol]
Phospho-Jnk1 [cytosol]
Jnk1 [cytosol]
MAPK8 [cytosol]
phospho-p-T,Y-MAPK8 [cytosol]
Inferred From
p-T,Y-MAPK8 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_446281.2
IntEnz
2.7.11.24
ZINC - Substances
MK08_RAT
ZINC target
P49185
PRO
P49185
ZINC - Predictions - Purchasable
MK08_RAT
RGD
621506
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19493
2
GRIA4 [endocytic vesicle membrane]
(R-RNO-416303)
GRIA4 [plasma membrane]
(R-RNO-392229)
0.544
2
UniProt:P19491-3 GRIA2
0.544
2
UniProt:P50232 SYT4
0.508
5
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