carbovir diphosphate + ATP => carbovir triphosphate + ADP

Stable Identifier
R-RNO-2162084
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Phosphorylation of carbovir diphosphate
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
carbovir diphosphate + ATP => carbovir triphosphate + ADP
Cytosolic PCK1 (phosphoenolpyruvate carboxykinase 1) catalyzes the reaction of carbovir diphosphate and ATP to form carbovir triphosphate and ADP. Notably, rat PCK1 catalyzed this reaction at approximately 70 times the rate of bovine nucleoside diphosphate kinase in vitro (Miller et al. 1992).
Literature References
PubMed ID Title Journal Year
1383219 Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity

Miller, WH, Boyd, FL, Miller, RL, Hopkins, S, Garvey, EP, Reardon, JE, Daluge, SM

J Biol Chem 1992
Participants
Input
Output
Catalyst Activity

nucleoside diphosphate kinase activity of Pck1 [cytosol]

Physical Entity
Pck1 [cytosol] (Rattus norvegicus)
Activity
nucleoside diphosphate kinase activity (GO:0004550)
Orthologous Events
carbovir diphosphate + ATP => carbovir triphosphate + ADP (Homo sapiens)
Authored
D'Eustachio, P  (2012-03-14)
Reviewed
Jassal, B  (2012-03-16)
Created
D'Eustachio, P  (2012-03-14)
Cite Us!