Photolytic cleavage and thermal isomerization of 7-dehydrocholesterol

Stable Identifier
R-RNO-209770
Type
Reaction [omitted]
Species
Rattus norvegicus
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
Photolytic cleavage and thermal isomerization of 7-dehydrocholesterol
The skin's exposure to UV rays from sunlight induces the photolytic cleavage of 7-dehydrocholesterol to previtamin D3. This is followed by thermal isomerization to form vitamin D3 (VD3, cholecalciferol) (Holick et al. 1977).
Literature References
PubMed ID Title Journal Year
194588 Photometabolism of 7-dehydrocholesterol to previtamin D3 in skin

McNeill, SC, Holick, MF, Henley, JW, Frommer, JE, Richtand, NM, Potts JT, Jr

Biochem Biophys Res Commun 1977
Participants
Input
Output
Orthologous Events
Photolytic cleavage and thermal isomerization of 7-dehydroCHOL (Homo sapiens)
Authored
Jassal, B  (2008-01-07)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-01-07)
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