Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Hdac1 [nucleoplasm]
Stable Identifier
R-RNO-205009
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
Histone deacetylase 1, HDAC1_RAT
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle, Mitotic (Rattus norvegicus)
Mitotic G1 phase and G1/S transition (Rattus norvegicus)
G0 and Early G1 (Rattus norvegicus)
Recruitment of HDAC1 by p107 (RBL1) (Rattus norvegicus)
HDAC1:RBL1:E2F4:TFDP1,TFDP2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Recruitment of HDAC1 by p130 (RBL2) (Rattus norvegicus)
HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Chromatin organization (Rattus norvegicus)
Chromatin modifying enzymes (Rattus norvegicus)
HDACs deacetylate histones (Rattus norvegicus)
HDAC1:2-containing complex binds HDAC2 Inhibitors (Rattus norvegicus)
HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
BHC complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
CoREST complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
NuRD complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Sin3A complex [nucleoplasm] (Rattus norvegicus)
Sin3a core complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Rattus norvegicus)
HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
BHC complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
CoREST complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
NuRD complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Sin3A complex [nucleoplasm] (Rattus norvegicus)
Sin3a core complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase I Transcription (Rattus norvegicus)
RNA Polymerase I Promoter Clearance (Rattus norvegicus)
RNA Polymerase I Transcription Initiation (Rattus norvegicus)
Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Rattus norvegicus)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Rattus norvegicus)
NuRD complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Notch-HLH transcription pathway (Rattus norvegicus)
Formation of CSL NCOR corepressor complex (Rattus norvegicus)
HDAC [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
RBPJ:NCOR corepressor complex [nucleoplasm] (Rattus norvegicus)
HDAC [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Transcriptional Regulation by MECP2 (Rattus norvegicus)
Regulation of MECP2 expression and activity (Rattus norvegicus)
MECP2 binds the SIN3A co-repressor complex (Rattus norvegicus)
MECP2:SIN3A:HDAC1,HDAC2 [nucleoplasm] (Rattus norvegicus)
MECP2:SIN3A:HDAC1 [nucleoplasm] (Rattus norvegicus)
SIN3A:HDAC1 homodimer [nucleoplasm] (Rattus norvegicus)
Hdac1 homodimer [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Rattus norvegicus)
SIN3A:HDAC1 homodimer [nucleoplasm] (Rattus norvegicus)
Hdac1 homodimer [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
Regulation of TP53 Activity (Rattus norvegicus)
Regulation of TP53 Activity through Acetylation (Rattus norvegicus)
MTA2-NuRD complex deacetylates TP53 (Rattus norvegicus)
MTA2-NuRD complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Rattus norvegicus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Transcriptional regulation by RUNX1 (Rattus norvegicus)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Rattus norvegicus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
RUNX1 binds SIN3A,(SIN3B) co-repressor (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Factors involved in megakaryocyte development and platelet production (Rattus norvegicus)
REST recruits the BHC complex (Rattus norvegicus)
BHC complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
BHC complex:REST:REST DNA binding sites [nucleoplasm] (Rattus norvegicus)
BHC complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
SUMOylation (Rattus norvegicus)
SUMO E3 ligases SUMOylate target proteins (Rattus norvegicus)
SUMOylation of chromatin organization proteins (Rattus norvegicus)
SUMOylation of HDAC1 with SUMO1 (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
PTEN Regulation (Rattus norvegicus)
Regulation of PTEN gene transcription (Rattus norvegicus)
SALL4 recruits NuRD to PTEN gene (Rattus norvegicus)
NuRD complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
SALL4:NuRD:PTEN gene [nucleoplasm] (Rattus norvegicus)
SALL4:NuRD [nucleoplasm] (Rattus norvegicus)
NuRD complex [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Estrogen-dependent gene expression (Rattus norvegicus)
FOXA1 and GATA3 bind to CCND1 promoter (Rattus norvegicus)
CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Signaling by TGFB family members (Rattus norvegicus)
Signaling by TGF-beta Receptor Complex (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Rattus norvegicus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Signaling by WNT (Rattus norvegicus)
TCF dependent signaling in response to WNT (Rattus norvegicus)
Deactivation of the beta-catenin transactivating complex (Rattus norvegicus)
beta-catenin is replaced by repression complexes at the promoter (Rattus norvegicus)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Rattus norvegicus)
TLE:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
TLE1:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
Formation of the beta-catenin:TCF transactivating complex (Rattus norvegicus)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Rattus norvegicus)
TLE:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q4QQW4 Hdac1
Gene Names
Hdac1
Chain
chain:1-482
Reference Genes
BioGPS Gene:297893 Hdac1
ENSEMBL:ENSRNOG00000009568 Hdac1
KEGG Gene (Rattus norvegicus):297893 Hdac1
Monarch:297893 Hdac1
NCBI Gene:297893 Hdac1
UCSC:Q4QQW4 Hdac1
Reference Transcript
RefSeq:NM_001025409.1 Hdac1
Other Identifiers
10880012
10929261
1388761_at
1396820_at
17810818
297893
5622685
5631536
5731857
5818804
5831681
5899058
5916883
5947251
5960570
5998451
6015995
6049603
6142089
6190798
6244524
6286039
6301005
6327035
6348371
6349177
6503058
A_64_P118296
A_64_P122452
GE17746
GO:0003674
GO:0004407
GO:0006464
GO:0008150
GO:0016575
GO:0016810
GO:0051276
PH_rn_0015141
rc_AA818418_at
Participates
as an input of
Recruitment of HDAC1 by p107 (RBL1) (Rattus norvegicus)
Recruitment of HDAC1 by p130 (RBL2) (Rattus norvegicus)
RUNX1 binds SIN3A,(SIN3B) co-repressor (Rattus norvegicus)
SUMOylation of HDAC1 with SUMO1 (Rattus norvegicus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
as a component of
CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Rattus norvegicus)
Hdac1 homodimer [nucleoplasm] (Rattus norvegicus)
HDAC1:HDAC2 [nucleoplasm] (Rattus norvegicus)
HDAC1:RBL1:E2F4:TFDP1,TFDP2 [nucleoplasm] (Rattus norvegicus)
HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Rattus norvegicus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Rattus norvegicus)
TLE1:HDAC1 [nucleoplasm] (Rattus norvegicus)
TLE:HDAC1 [nucleoplasm] (Rattus norvegicus)
as a member of
HDAC [nucleoplasm] (Rattus norvegicus)
Histone deacetylase [nucleoplasm] (Rattus norvegicus)
as an output of
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Rattus norvegicus)
FOXA1 and GATA3 bind to CCND1 promoter (Rattus norvegicus)
Other forms of this molecule
Hdac1 [nucleoplasm]
Inferred From
HDAC1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001020580.1
IntEnz
3.5.1.98
ZINC - Substances
HDAC1_RAT
ZINC target
Q4QQW4
Ensembl
ENSRNOG00000009568
,
ENSRNOP00000012854
,
ENSRNOT00000012854
PRO
Q4QQW4
RGD
1309799
ZINC - Predictions - Purchasable
HDAC1_RAT
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
