Reactome | Dusp4 [nucleoplasm]

Dusp4 [nucleoplasm]

Stable Identifier

R-RNO-203794

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

DUSP4, Q62767

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-17 signaling (Rattus norvegicus)
      - MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        ERK/MAPK targets (Rattus norvegicus)
        
        ERKs are inactivated (Rattus norvegicus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
        
        ERK-specific DUSP [nucleoplasm] (Rattus norvegicus)
        
        Dusp4 [nucleoplasm] (Rattus norvegicus)
- Innate Immune System (Rattus norvegicus)
  - Toll-like Receptor Cascades (Rattus norvegicus)
    - Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        ERK/MAPK targets (Rattus norvegicus)
        
        ERKs are inactivated (Rattus norvegicus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
        
        ERK-specific DUSP [nucleoplasm] (Rattus norvegicus)
        
        Dusp4 [nucleoplasm] (Rattus norvegicus)
    - Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        ERK/MAPK targets (Rattus norvegicus)
        
        ERKs are inactivated (Rattus norvegicus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
        
        ERK-specific DUSP [nucleoplasm] (Rattus norvegicus)
        
        Dusp4 [nucleoplasm] (Rattus norvegicus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        ERK/MAPK targets (Rattus norvegicus)
        
        ERKs are inactivated (Rattus norvegicus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
        
        ERK-specific DUSP [nucleoplasm] (Rattus norvegicus)
        
        Dusp4 [nucleoplasm] (Rattus norvegicus)
    - Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
      - MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        ERK/MAPK targets (Rattus norvegicus)
        
        ERKs are inactivated (Rattus norvegicus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
        
        ERK-specific DUSP [nucleoplasm] (Rattus norvegicus)
        
        Dusp4 [nucleoplasm] (Rattus norvegicus)
    - Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
      - MyD88-independent TLR4 cascade (Rattus norvegicus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        ERK/MAPK targets (Rattus norvegicus)
        
        ERKs are inactivated (Rattus norvegicus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
        
        ERK-specific DUSP [nucleoplasm] (Rattus norvegicus)
        
        Dusp4 [nucleoplasm] (Rattus norvegicus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        ERK/MAPK targets (Rattus norvegicus)
        
        ERKs are inactivated (Rattus norvegicus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
        
        ERK-specific DUSP [nucleoplasm] (Rattus norvegicus)
        
        Dusp4 [nucleoplasm] (Rattus norvegicus)
    - Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        ERK/MAPK targets (Rattus norvegicus)
        
        ERKs are inactivated (Rattus norvegicus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
        
        ERK-specific DUSP [nucleoplasm] (Rattus norvegicus)
        
        Dusp4 [nucleoplasm] (Rattus norvegicus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        ERK/MAPK targets (Rattus norvegicus)
        
        ERKs are inactivated (Rattus norvegicus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
        
        ERK-specific DUSP [nucleoplasm] (Rattus norvegicus)
        
        Dusp4 [nucleoplasm] (Rattus norvegicus)
    - Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
        
        ERK/MAPK targets (Rattus norvegicus)
        
        ERKs are inactivated (Rattus norvegicus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)
        
        ERK-specific DUSP [nucleoplasm] (Rattus norvegicus)
        
        Dusp4 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q62767

Gene Names

Dusp4

Reference Genes

BioGPS Gene:60587 Dusp4

ENSEMBL:ENSRNOG00000011921

KEGG Gene (Rattus norvegicus):60587 Dusp4

Monarch:60587 Dusp4

NCBI Gene:60587 Dusp4

Reference Transcript

RefSeq:NM_022199.1 Dusp4

Participates

as a candidate of

nuclear MAPK DUSPs [nucleoplasm] (Rattus norvegicus)

as a member of

ERK-specific DUSP [nucleoplasm] (Rattus norvegicus)

Inferred From

DUSP4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_071535.1

IntEnz

3.1.3.16

PRO

Q62767

RGD

620625

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