Reactome | phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol]

phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol]

Stable Identifier

R-RNO-202357

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

P10686

Locations in the PathwayBrowser for interactor UniProt:Q63537

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External Reference Information

External Reference

UniProt:P10686 Plcg1

Gene Names

Plcg1

Chain

initiator methionine:, chain:2-1290

Reference Genes

BioGPS Gene:25738 Plcg1

KEGG Gene (Rattus norvegicus):25738 Plcg1

Monarch:25738 Plcg1

NCBI Gene:25738 Plcg1

UCSC:P10686 Plcg1

Reference Transcript

RefSeq:NM_013187.1 Plcg1

Participates

as an input of

Translocation of PLC-gamma1 to PIP2 (Rattus norvegicus)

as an output of

as a component of

Other forms of this molecule

p-4Y-Plcg1 [plasma membrane]

phospho-p-Y771,Y783-PLCG1 [plasma membrane]

p-Plcg1 [plasma membrane]

Plcg1 [plasma membrane]

PLCG1 [plasma membrane]

PLCG1 [cytosol]

phospho-p-4Y-PLCG1 [plasma membrane]

Inferred From

p-Y771,Y783,Y1254-PLCG1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 771

Coordinate

771

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 783

Coordinate

783

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1253

Coordinate

1253

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_037319.1

ZINC target

P10686

PRO

P10686

RGD

3347

PDB

6PBC, 3GQI, 1YWP, 7T8T, 5EG3, 4K44, 1YWO, 4K45, 2FJL, 1Y0M, 7Z3J

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11362 FGFR1	9	FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) FGFR1 [plasma membrane] (R-HSA-9756433)	0.611	4
UniProt:Q8CGU4 Agap2	1	PIKE-L_RAT [cytosol] (R-RNO-622356)	0.602	4
UniProt:Q63537	1	Syn2 [clathrin-sculpted monoamine transport vesicle membrane] (R-RNO-380579)	0.602	5
UniProt:Q08881 ITK	3	p-Y180,Y512-ITK [cytosol] (R-HSA-2685616) p-Y512-ITK [cytosol] (R-HSA-422519) ITK [cytosol] (R-HSA-202319)	0.59	2
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.556	4
UniProt:Q9ES52 Inpp5d	3	p-Y-Inpp5d [cytosol] (R-MMU-9680732) Inpp5d [cytosol] (R-MMU-9680650) Inpp5d [cytosol] (R-MMU-197940)	0.524	3
UniProt:Q13507 TRPC3	1	TRPC3(1-848) [plasma membrane] (R-HSA-426172)	0.508	2
UniProt:Q62120 Jak2	11	phospho-p-Y1007,Y1008-JAK2 [cytosol] (R-MMU-9005327) p-Jak2 [cytosol] (R-MMU-8950633) phospho-p-JAK2 [cytosol] (R-MMU-210621) phospho-p-Y813-JAK2 [cytosol] (R-MMU-997248) JAK2 [endosome lumen] (R-MMU-2002372) JAK2 [cytosol] (R-MMU-210620) phospho-p-Y1007-JAK2 [cytosol] (R-MMU-873799) Jak2 [cytosol] (R-MMU-205743) phospho-p-12Y-JAK2 [cytosol] (R-MMU-2586516) p-Y1007-Jak2 [cytosol] (R-MMU-997296) p-12Y-Jak2 [cytosol] (R-MMU-2586515)	0.463	3

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