Reactome | phospho-Cd3d [plasma membrane]

phospho-Cd3d [plasma membrane]

Stable Identifier

R-RNO-202329

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

p-Y149,Y160-CD3D, P19377

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Costimulation by the CD28 family (Rattus norvegicus)
    - PD-1 signaling (Rattus norvegicus)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)
  - TCR signaling (Rattus norvegicus)
    - Generation of second messenger molecules (Rattus norvegicus)
      - Phosphorylation of PLC-gamma1 (Rattus norvegicus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of SLP-76 (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of TBSMs in LAT (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)
    - Phosphorylation of CD3 and TCR zeta chains (Rattus norvegicus)
      - Phosphorylation of ITAM motifs in CD3 complexes (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)
    - Translocation of ZAP-70 to Immunological synapse (Rattus norvegicus)
      - Activation of ZAP-70 (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)
      - PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of ZAP-70 by Lck (Rattus norvegicus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        phospho-Cd3d [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P19377

Gene Names

Cd3d

Reference Genes

BioGPS Gene:25710 Cd3d

ENSEMBL:ENSRNOG00000015994

KEGG Gene (Rattus norvegicus):25710 Cd3d

Monarch:25710 Cd3d

NCBI Gene:25710 Cd3d

UCSC:P19377 Cd3d

Reference Transcript

RefSeq:NM_013169.1 Cd3d

Participates

as a component of

CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

Cd3d [clathrin-coated endocytic vesicle membrane]

Cd3d [plasma membrane]

Inferred From

p-Y149,Y160-CD3D [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 149 (in Homo sapiens)

Coordinate

149

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 160 (in Homo sapiens)

Coordinate

160

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_037301.1

PRO

P19377

RGD

2304

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