Reactome | FEM1B [cytosol]

FEM1B [cytosol]

Stable Identifier

R-RNO-201572

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

P0C6P7

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        FEM1B [cytosol] (Rattus norvegicus)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        FEM1B [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        FEM1B [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        FEM1B [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        FEM1B [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        FEM1B [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        FEM1B [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        FEM1B [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        FEM1B [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        FEM1B [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P0C6P7

Reference Genes

BioGPS Gene:315745

ENSEMBL:ENSRNOG00000007077

ENSEMBL:ENSRNOG00000007077.7

ENSEMBL:ENSRNOG00055025039

ENSEMBL:ENSRNOG00060018951

ENSEMBL:ENSRNOG00065007875

KEGG Gene (Rattus norvegicus):315745

Monarch:315745

NCBI Gene:315745

UCSC:P0C6P7

Reference Transcript

RefSeq:NM_001108157.1

Other Identifiers

10918089

1386643_at

1393843_at

17853299

315745

6138425

6348871

6424284

6520975

A_44_P142817

GO:0002070

GO:0005123

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0012501

GO:0016567

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0031462

GO:0036211

GO:0043161

GO:0043226

GO:0048856

GO:0060090

GO:0060442

GO:0060743

GO:0140627

GO:1902041

GO:1990756

GO:2000001

ILMN_1357677

PH_rn_0015696

rc_AI071911_at

Participates

as a member of

CUL2-box protein [cytosol] (Rattus norvegicus)

Inferred From

FEM1B [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001101627.1

Ensembl

ENSRNOG00000007077, ENSRNOP00000009368, ENSRNOT00000009368

PRO

P0C6P7

RGD

1304569