Akt translocates to the nucleus

Stable Identifier
R-RNO-198333
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Akt translocates to the nucleus
AKT, phosphorylated at threonine (AKT1 308; AKT2 309; AKT3 305) and serine (AKT1 473; AKT2 474; AKT3 472) translocates to the nucleus, reaching a maximum after 15 min and returning to a basal level after 45 min of NGF stimulation. Control of the amount of nuclear AKT is achieved through the action of the phosphatase PP2A (Borgatti et al. 2003).
Literature References
PubMed ID Title Journal Year
12767043 Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin

Neri, LM, Capitani, S, Bellacosa, A, Tabellini, G, Martelli, AM, Borgatti, P

J Cell Physiol 2003
Participants
Orthologous Events
Reviewed
Created
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