Reactome | ENSRNOG00000065769 [plasma membrane]

ENSRNOG00000065769 [plasma membrane]

Stable Identifier

R-RNO-198180

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

TCRA, A0A8I6A4Z0

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Costimulation by the CD28 family (Rattus norvegicus)
    - PD-1 signaling (Rattus norvegicus)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Rattus norvegicus)
    - TCR binds microbial lipid-based antigen via CD1 (Rattus norvegicus)
      - CD1:B2M:microbial lipid:TCR [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
      - T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
    - TCR binds self-lipid-based antigen via CD1 (Rattus norvegicus)
      - CD1:B2M:self-lipid:TCR [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
      - T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
    - TCR complex interacts with peptide antigen-presenting MHC Class I (Rattus norvegicus)
      - T-cell receptor complex with CD8 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
      - TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with CD8 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
  - TCR signaling (Rattus norvegicus)
    - Downstream TCR signaling (Rattus norvegicus)
      - Change of PKC theta conformation (Rattus norvegicus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
    - Generation of second messenger molecules (Rattus norvegicus)
      - Phosphorylation of PLC-gamma1 (Rattus norvegicus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of SLP-76 (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of TBSMs in LAT (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
    - Phosphorylation of CD3 and TCR zeta chains (Rattus norvegicus)
      - Activation of Lck (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
      - Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
      - Inactivation of LCK by PTPN22 (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
      - Inactivation of Lck by Csk (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of ITAM motifs in CD3 complexes (Rattus norvegicus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
    - Translocation of ZAP-70 to Immunological synapse (Rattus norvegicus)
      - Activation of ZAP-70 (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
      - PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of ZAP-70 by Lck (Rattus norvegicus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Rattus norvegicus)
        
        T-cell receptor [plasma membrane] (Rattus norvegicus)
        
        TCR chain alpha [plasma membrane] (Rattus norvegicus)
        
        ENSRNOG00000065769 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A8I6A4Z0

Gene Names

ENSRNOG00000065769

Reference Genes

ENSEMBL:ENSRNOG00000065769.1

Other Identifiers

17698579

5682574

5706934

5934451

6122086

6449140

6659336

ILMN_1369613

L11035_g_at

PH_rn_0019950

Participates

as a member of

TCR chain alpha [plasma membrane] (Rattus norvegicus)

Inferred From

TCRA [plasma membrane] (Homo sapiens)

Cross References

Ensembl

ENSRNOT00000097076, ENSRNOG00000065769, ENSRNOP00000087734

RGD

150341929

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