Reactome | Fcgr1a [plasma membrane]

Fcgr1a [plasma membrane]

Stable Identifier

R-RNO-197835

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

FCGR1A, A0A0B4J2J0

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
    - Antigen processing-Cross presentation (Rattus norvegicus)
      - Cross-presentation of soluble exogenous antigens (endosomes) (Rattus norvegicus)
        
        Internalization of receptor bound antigen into clathrin coted vesicles (Rattus norvegicus)
        
        MR:soluble antigen [plasma membrane] (Rattus norvegicus)
        
        MR/other probable receptors [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
- Innate Immune System (Rattus norvegicus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
    - FCGR activation (Rattus norvegicus)
      - Cross-linking of FCGRIA with IgG-coated Ag (Rattus norvegicus)
        
        FCGRIA:CD3G homodimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
        
        IgG-Ag:FCGRIA:CD3G homodimer [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:CD3G homodimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
      - Recruitment of SYK to phosphorylated ITAMs (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
      - Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Rattus norvegicus)
        
        clustered IgG-Ag:FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:CD3G homodimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
    - Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Rattus norvegicus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
      - Activation of RAC1 by VAV (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
      - Phosphorylation of VAV (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
      - Recruitment of VAV1 to p-6Y-SYK (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
      - Role of myosins in phagosome formation (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
    - Role of phospholipids in phagocytosis (Rattus norvegicus)
      - PI3K binds to p-6Y-SYK (Rattus norvegicus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
      - PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
      - Phosphorylation and activation of PLCG (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
      - Recruitment of PLCgamma to membrane (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
      - Release of PLCG from FCGR (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        p-FCGRs [plasma membrane] (Rattus norvegicus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Rattus norvegicus)
        
        Fcgr1a [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A0B4J2J0

Gene Names

Fcgr1a

Reference Genes

BioGPS Gene:295279 Fcgr1a

ENSEMBL:ENSRNOG00000021199

ENSEMBL:ENSRNOG00000021199.6 Fcgr1a

KEGG Gene (Rattus norvegicus):295279 Fcgr1a

Monarch:295279 Fcgr1a

NCBI Gene:295279 Fcgr1a

Reference Transcript

RefSeq:NM_001100836.1 Fcgr1a

Other Identifiers

10825153

1393038_at

17749620

295279

5636009

5720278

5727128

5813532

6037287

6154239

6165946

6380473

A_43_P15904

A_64_P129279

GE1118717

GE16785

ILMN_1362025

PH_rn_0011222

rc_AA848930_at

Participates

as a component of

as a member of

MR/other probable receptors [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

Fcgr1a [clathrin-coated endocytic vesicle membrane]

Fcgr1a [early endosome membrane]

Inferred From

FCGRA [plasma membrane] (Homo sapiens)

FCGR1A [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001094306.1

Ensembl

ENSRNOG00000021199, ENSRNOP00000028780, ENSRNOT00000028780

RGD

1309912

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