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Vav2 [cytosol]
Stable Identifier
R-RNO-195012
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
VAV2, D3ZYG0
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
EPH-Ephrin signaling (Rattus norvegicus)
EPH-ephrin mediated repulsion of cells (Rattus norvegicus)
SFKs phosphorylate VAV2,3 (Rattus norvegicus)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
p-EPHs bind VAV2,3 (Rattus norvegicus)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
VAV1 is a GEF for Rho/Rac family GTPases (Rattus norvegicus)
PIP3:VAV1,2,3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
VAV family:PIP2 [plasma membrane] (Rattus norvegicus)
VAV family [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
p-SLP-76 binds VAV (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
p-SLP-76:VAV [cytosol] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
DAP12 interactions (Rattus norvegicus)
DAP12 signaling (Rattus norvegicus)
Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Phosphorylation of BTK by p-SYK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
p-SYK/p-BTK [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Recruitment of VAV and BTK to p-SLP-76 (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Release of p-PLCG1 (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated Ca+2 mobilization (Rattus norvegicus)
Autophosphorylation of BTK/ITK (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Hydrolysis of PIP2 by PLCG (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Phosphorylation of TEC kinases by p-SYK (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
FCERI mediated MAPK activation (Rattus norvegicus)
Phosphorylation and activation of VAV (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Recruitment of VAV to p-SLP-76 (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
Phosphorylation of VAV (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Recruitment of VAV1 to p-6Y-SYK (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
Cell death signalling via NRAGE, NRIF and NADE (Rattus norvegicus)
NRAGE signals death through JNK (Rattus norvegicus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Rattus norvegicus)
GEFs [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (12/13) signalling events (Rattus norvegicus)
GEFs activate RhoA,B,C (Rattus norvegicus)
GEFs [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
Src kinases phosphorylate VAV (Rattus norvegicus)
PIP3:VAV1,2,3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
VAV family [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase cycle (Rattus norvegicus)
CDC42 GTPase cycle (Rattus norvegicus)
CDC42 GEFs activate CDC42 (Rattus norvegicus)
CDC42 GEFs [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
RAC1 GTPase cycle (Rattus norvegicus)
RAC1 GEFs activate RAC1 (Rattus norvegicus)
RAC1 GEFs [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
RAC2 GTPase cycle (Rattus norvegicus)
RAC2 GEFs activate RAC2 (Rattus norvegicus)
RAC2 GEFs [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
RHOA GTPase cycle (Rattus norvegicus)
RHOA GEFs activate RHOA (Rattus norvegicus)
RHOA GEFs [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
RHOB GTPase cycle (Rattus norvegicus)
RHOB GEFs activate RHOB (Rattus norvegicus)
RHOB GEFs [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
RHOG GTPase cycle (Rattus norvegicus)
RHOG GEFs activate RHOG (Rattus norvegicus)
RHOG GEFs [cytosol] (Rattus norvegicus)
Vav2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:D3ZYG0
Gene Names
Vav2
Reference Genes
BioGPS Gene:296603 Vav2
ENSEMBL:ENSRNOG00000007422
ENSEMBL:ENSRNOG00000007422.7 Vav2
KEGG Gene (Rattus norvegicus):296603 Vav2
Monarch:296603 Vav2
NCBI Gene:296603 Vav2
UCSC:D3ZYG0 Vav2
Reference Transcript
RefSeq:NM_001106563.2 Vav2
Other Identifiers
10843959
1384169_a_at
1384170_at
1384171_x_at
1393349_x_at
17770874
296603
5626801
5640333
5720421
5736773
5765420
5813317
5874270
5896299
5964475
5970049
5971664
6099207
6106127
6113932
6136833
6148168
6156588
6185843
6247651
6262640
6290614
6317692
6322028
6331070
6388799
6456380
6503403
6518333
6543422
6578420
6592677
6611096
6647360
6702360
A_44_P876363
GE1126699
GE1178784
GO:0001784
GO:0005085
GO:0005154
GO:0005515
GO:0005737
GO:0005886
GO:0007264
GO:0016477
GO:0023052
GO:0030031
GO:0030032
GO:0035556
GO:0048870
GO:0051897
GO:0098772
ILMN_1368914
ILMN_1375184
PH_rn_0007364
rc_AA819193_at
rc_AA819193_g_at
rc_AA893593_at
rc_AA893593_g_at
rc_AA900477_s_at
rc_AI177124_at
Participates
as a member of
RHOA GEFs [cytosol] (Rattus norvegicus)
RAC2 GEFs [cytosol] (Rattus norvegicus)
RAC1 GEFs [cytosol] (Rattus norvegicus)
RHOB GEFs [cytosol] (Rattus norvegicus)
VAV family [cytosol] (Rattus norvegicus)
GEFs [cytosol] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
as a candidate of
CDC42 GEFs [cytosol] (Rattus norvegicus)
RHOG GEFs [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-Vav2 [cytosol]
Inferred From
VAV2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001100033.2
Ensembl
ENSRNOG00000007422
,
ENSRNOP00000009893
,
ENSRNOT00000009893
RGD
1306285
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