Sphingomyelinase is activated by the NGF:p75NTR complex

Stable Identifier
R-RNO-194339
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Sphingomyelinase is activated by the NGF:p75NTR complex

NGF binding to p75NTR activates N-SMase (Neutral sphingomyelinase), and possibly A-SMase (acid sphingomyelinase), an enzyme that converts sphingomyelin to ceramide. The mode and mechanism of interaction between p75 and N-SMase have not been determined but is thought to involve the recruitment of Mg2+ to the active site of the enzyme.

Literature References
PubMed ID Title Journal Year
7673191 Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors.

Jenkins, GM, Hannun, YA

J Biol Chem 1995
Participants
Catalyst Activity

transmembrane signaling receptor activity of mature NGF:p75NTR [plasma membrane]

Orthologous Events
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