Adcyap1 binds Adcyap1r1 and Ntrk1,2,3

Stable Identifier
R-RNO-189632
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
Golgi membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Adcyap1 binds Adcyap1r1 and Ntrk1,2,3
Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of nerve growth factor receptor tyrosine kinases (NTRKs). Pituitary adenylate cyclase-activating polypeptide (ADCYAP1), a neuromodulator acting through type 1 PACAP receptors (ADCYAP1R1), can transactivate NTRKs in the absence of neurotrophins (Jeanneteau & Chao 2006). The mechanism of this activation is not fully understood. First, ADCYAP1 binds ADCYAP1R1 and NTRK1 and NTRK2.
Literature References
PubMed ID Title Journal Year
11784714 Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides

Lee, FS, Rajagopal, R, Kim, AH, Chang, PC, Chao, MV

J Biol Chem 2002
Participants
Input
Output
Catalyst Activity

pituitary adenylate cyclase-activating polypeptide receptor activity of Adcyap1r1 [Golgi membrane]

Physical Entity
Adcyap1r1 [Golgi membrane] (Rattus norvegicus)
Activity
pituitary adenylate cyclase-activating polypeptide receptor activity (GO:0001634)
Orthologous Events
ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 (Homo sapiens)
Created
Jassal, B  (2006-12-01)
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