Reactome | phospho-Mapkapk3 [cytosol]

phospho-Mapkapk3 [cytosol]

Stable Identifier

R-RNO-187723

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

p-S,2T-MAPKAPK3, Q66H84

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-17 signaling (Rattus norvegicus)
      - MAP kinase activation (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)
        
        p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        phospho-Mapkapk3 [cytosol] (Rattus norvegicus)
- Innate Immune System (Rattus norvegicus)
  - Toll-like Receptor Cascades (Rattus norvegicus)
    - Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)
        
        p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        phospho-Mapkapk3 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)
        
        p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        phospho-Mapkapk3 [cytosol] (Rattus norvegicus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)
        
        p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        phospho-Mapkapk3 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
      - MAP kinase activation (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)
        
        p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        phospho-Mapkapk3 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
      - MyD88-independent TLR4 cascade (Rattus norvegicus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)
        
        p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        phospho-Mapkapk3 [cytosol] (Rattus norvegicus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)
        
        p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        phospho-Mapkapk3 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)
        
        p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        phospho-Mapkapk3 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)
        
        p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        phospho-Mapkapk3 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
        
        Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)
        
        p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)
        
        phospho-Mapkapk3 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q66H84

Gene Names

Mapkapk3

Reference Genes

BioGPS Gene:315994 Mapkapk3

ENSEMBL:ENSRNOG00000014832

KEGG:rno:315994 Mapkapk3

Monarch:315994 Mapkapk3

NCBI Gene:315994 Mapkapk3

UCSC:Q66H84 Mapkapk3

Reference Transcript

Other Identifiers

10920056

1372546_at

17855510

315994

5645309

5670819

5814427

5830661

5867857

5888355

5922870

5925818

5932878

5961790

5981603

6093397

6125665

6219179

6225335

6271753

6455659

6510710

6614109

6622713

6635601

6705939

A_44_P212887

A_64_P150246

GE1236303

GO:0000165

GO:0002224

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0005524

GO:0005654

GO:0006468

GO:0016192

GO:0016740

GO:0032496

GO:0034097

GO:0044351

GO:0140096

ILMN_1376086

ILMN_1530406

PH_rn_0002596

rc_AA955477_at

rc_AA955477_g_at

rc_AI011376_at

rc_AI229421_at

Participates

as a member of

p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Rattus norvegicus)

Other forms of this molecule

Mapkapk3 [cytosol]

phospho-Mapkapk3 [nucleoplasm]

Mapkapk3 [nucleoplasm]

Inferred From

p-S,2T-MAPKAPK3 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at unknown position

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at unknown position

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_008764753.1, XP_006243838.1, NP_001012127.1

ENSEMBL

ENSRNOP00000020065, ENSRNOT00000020065, ENSRNOG00000014832

IntEnz

2.7.11.1

PRO

Q66H84

RGD

1304980

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