Calcium release from intracellular stores by IP3 receptor activation

Stable Identifier
R-RNO-182097
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Calcium release from intracellular stores by IP3 receptor activation

Calcium is released from the ER to the cytosol upon IP3 receptor activation

Literature References
PubMed ID Title Journal Year
11285228 Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathways

Canossa, M, Inagaki, N, Campana, G, Thoenen, H, Gartner, A

EMBO J 2001
Participants
Input
Output
Catalyst Activity

cation channel activity of IP3 receptor:IP3 [endoplasmic reticulum membrane]

Physical Entity
IP3 receptor:IP3 [endoplasmic reticulum membrane] (Rattus norvegicus)
Activity
cation channel activity (GO:0005261)
Orthologous Events
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT (Homo sapiens)
Authored
Jassal, B  (2004-03-31)
Le Novere, N  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Jassal, B  (2006-07-06)
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