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Cul5 [cytosol]
Stable Identifier
R-RNO-180528
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
CUL5, Q9JJ31
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
Polyubiquitination of substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by CSF3 (G-CSF) (Rattus norvegicus)
Inactivation of CSF3 (G-CSF) signaling (Rattus norvegicus)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Neddylation (Rattus norvegicus)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ERBB2 (Rattus norvegicus)
Downregulation of ERBB2 signaling (Rattus norvegicus)
CUL5 mediates ubiquitination of ERBB2 (Rattus norvegicus)
Cul5 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q9JJ31
Gene Names
Cul5
Reference Genes
BioGPS Gene:64624 Cul5
ENSEMBL:ENSRNOG00000008039
KEGG:rno:64624 Cul5
Monarch:64624 Cul5
NCBI Gene:64624 Cul5
UCSC:Q9JJ31 Cul5
Reference Transcript
RefSeq:NM_022683.1 Cul5
Participates
as an output of
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Rattus norvegicus)
as a component of
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Rattus norvegicus)
CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
Cul5-SCF complex [cytosol] (Rattus norvegicus)
Other forms of this molecule
Cul5 [cytosol]
Inferred From
CUL5 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_073174.1
PRO
Q9JJ31
RGD
621742
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