Reactome | Rad9b [nucleoplasm]

Rad9b [nucleoplasm]

Stable Identifier

R-RNO-176325

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

RAD9B, Q499V3

Locations in the PathwayBrowser

Expand all

Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - G2/M Checkpoints (Rattus norvegicus)
    - Activation of ATR in response to replication stress (Rattus norvegicus)
      - Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
    - G2/M DNA damage checkpoint (Rattus norvegicus)
      - ATR phosphorylates TP53 (Rattus norvegicus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)

DNA Repair (Rattus norvegicus)

- DNA Double-Strand Break Repair (Rattus norvegicus)
  - Homology Directed Repair (Rattus norvegicus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Rattus norvegicus)
      - HDR through Homologous Recombination (HRR) (Rattus norvegicus)
        
        Homologous DNA Pairing and Strand Exchange (Rattus norvegicus)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Rattus norvegicus)
        
        RAD51 binds BRCA2 at resected DNA DSBs (Rattus norvegicus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
      - HDR through Single Strand Annealing (SSA) (Rattus norvegicus)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Rattus norvegicus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Rattus norvegicus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Rattus norvegicus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
      - Processing of DNA double-strand break ends (Rattus norvegicus)
        
        ATR activation at DNA DSBs (Rattus norvegicus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        ATR phosphorylates RPA2 (Rattus norvegicus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        Activation of CHEK1 at resected DNA DSBs (Rattus norvegicus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        CHEK1 is recruited to resected DNA DSBs (Rattus norvegicus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional Regulation by TP53 (Rattus norvegicus)
      - Regulation of TP53 Activity (Rattus norvegicus)
        
        Regulation of TP53 Activity through Phosphorylation (Rattus norvegicus)
        
        ATR phosphorylates TP53 (Rattus norvegicus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Rattus norvegicus)
        
        RAD9 [nucleoplasm] (Rattus norvegicus)
        
        Rad9b [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q499V3

Gene Names

Rad9b

Reference Genes

BioGPS Gene:363924 Rad9b

ENSEMBL:ENSRNOG00000021480

ENSEMBL:ENSRNOG00000021480 Rad9b

KEGG Gene (Rattus norvegicus):363924 Rad9b

Monarch:363924 Rad9b

NCBI Gene:363924 Rad9b

UCSC:Q499V3 Rad9b

Reference Transcript

RefSeq:NM_001030042.1 Rad9b

Other Identifiers

10758587

1384876_at

17673997

363924

5669294

5756840

5855170

5898381

6036841

6187394

6240969

6336497

6353133

6367025

6474147

6597896

6656399

A_44_P363330

A_64_P031219

GE1162589

GO:0000076

GO:0000077

GO:0000228

GO:0000278

GO:0003674

GO:0004518

GO:0005575

GO:0005622

GO:0005634

GO:0005694

GO:0006259

GO:0006281

GO:0006950

GO:0007049

GO:0008150

GO:0008408

GO:0030896

GO:0031573

GO:0032991

GO:0034641

GO:0043226

GO:0071479

GO:0090305

ILMN_1364902

PH_rn_0003070

Participant Of

hasMember

RAD9 [nucleoplasm]

Inferred From

RAD9B [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001025213.1

Ensembl

ENSRNOP00000042520, ENSRNOT00000048454, ENSRNOG00000021480

PRO

Q499V3

RGD

1308223

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