Reactome | phospho-Clspn [nucleoplasm]

phospho-Clspn [nucleoplasm]

Stable Identifier

R-RNO-176296

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

p-T916,S945-CLSPN, D3ZHC3

Locations in the PathwayBrowser

Expand all

Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - G2/M Checkpoints (Rattus norvegicus)
    - Activation of ATR in response to replication stress (Rattus norvegicus)
      - Activation of claspin (Rattus norvegicus)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Rattus norvegicus)
        
        phospho-Clspn [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZHC3

Gene Names

Clspn

Reference Genes

BioGPS Gene:298534 Clspn

ENSEMBL:ENSRNOG00000011332

ENSEMBL:ENSRNOG00000011332 Clspn

KEGG Gene (Rattus norvegicus):298534 Clspn

Monarch:298534 Clspn

NCBI Gene:298534 Clspn

Reference Transcript

RefSeq:NM_001106687.1 Clspn

Other Identifiers

10872032

10872057

1391077_at

17802144

298534

5642891

5717286

5798633

5816551

5835927

5879254

5943357

6021023

6025847

6046993

6047412

6067088

6102706

6126810

6136218

6167080

6259742

6301642

6307425

6325094

6360818

6374144

6396493

6419348

6437941

6497955

6561130

6600727

6628181

6735991

A_44_P494754

A_44_P680622

GE1193254

GO:0000076

GO:0000077

GO:0000217

GO:0000278

GO:0003674

GO:0003677

GO:0005575

GO:0005622

GO:0005634

GO:0006464

GO:0006950

GO:0007049

GO:0007095

GO:0008150

GO:0010997

GO:0018105

GO:0032147

GO:0033314

GO:0043226

ILMN_1356996

PH_rn_0010029

rc_AA851257_at

Participant Of

hasComponent

input

CHEK1 is recruited to resected DNA DSBs

output

Activation of CHEK1 at resected DNA DSBs

Other forms of this molecule

Clspn [nucleoplasm]

Inferred From

p-T916,S945-CLSPN [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 945 (in Homo sapiens)

Coordinate

945

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 916 (in Homo sapiens)

Coordinate

916

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001100157.1

Ensembl

ENSRNOG00000011332, ENSRNOT00000015227, ENSRNOP00000015227

RGD

1309083