Reactome | SYT2 [plasma membrane]

SYT2 [plasma membrane]

Stable Identifier

R-RNO-168795

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

P29101

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - STON2 binds SYT proteins (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT2 dimer [plasma membrane] (Rattus norvegicus)
        
        SYT2 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P29101

Reference Genes

BioGPS Gene:24805

ENSEMBL:ENSRNOG00000004756

ENSEMBL:ENSRNOG00055021595

ENSEMBL:ENSRNOG00060014883

ENSEMBL:ENSRNOG00065021046

KEGG Gene (Rattus norvegicus):24805

Monarch:24805

NCBI Gene:24805

UCSC:P29101

Reference Transcript

RefSeq:NM_012665.1

Participates

as a component of

SYT2 dimer [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

SYT2 [clathrin-coated endocytic vesicle membrane]

Inferred From

SYT2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_036797.1

PRO

P29101

RGD

3804

PDB

4ISR, 2NM1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10844 botB	8	botB HC [synaptic vesicle membrane] (R-CBO-5228953) botB LC [cytosol] (R-CBO-181489) botB LC disulfide bonded [extracellular region] (R-CBO-181565) botB LC disulfide bonded [plasma membrane] (R-CBO-181466) botB HC disulfide bonded [plasma membrane] (R-CBO-181485) botB HC disulfide bonded [synaptic vesicle membrane] (R-CBO-181459) botB LC disulfide bonded [synaptic vesicle membrane] (R-CBO-181465) botB HC disulfide bonded [extracellular region] (R-CBO-181507)	0.766	6

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