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phospho-p-4Y-PLCG1 [plasma membrane]
Stable Identifier
R-RNO-167679
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
P10686
Locations in the PathwayBrowser for interactor UniProt:Q63537
Expand all
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by EGFR (Rattus norvegicus)
EGFR interacts with phospholipase C-gamma (Rattus norvegicus)
Active PLC-gamma1 dissociates from EGFR (Rattus norvegicus)
phospho-p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
Signaling by FGFR (Rattus norvegicus)
Signaling by FGFR1 (Rattus norvegicus)
Downstream signaling of activated FGFR1 (Rattus norvegicus)
Phospholipase C-mediated cascade: FGFR1 (Rattus norvegicus)
p-4Y-PLCG1 dissociates from activated FGFR1 (Rattus norvegicus)
phospho-p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
Signaling by FGFR2 (Rattus norvegicus)
Downstream signaling of activated FGFR2 (Rattus norvegicus)
Phospholipase C-mediated cascade; FGFR2 (Rattus norvegicus)
p-4Y-PLCG1 dissociates from activated FGFR2 (Rattus norvegicus)
phospho-p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
Signaling by FGFR3 (Rattus norvegicus)
Downstream signaling of activated FGFR3 (Rattus norvegicus)
Phospholipase C-mediated cascade; FGFR3 (Rattus norvegicus)
p-4Y-PLCG1 dissociates from activated FGFR3 (Rattus norvegicus)
phospho-p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
Signaling by FGFR4 (Rattus norvegicus)
Downstream signaling of activated FGFR4 (Rattus norvegicus)
Phospholipase C-mediated cascade; FGFR4 (Rattus norvegicus)
p-4Y-PLCG1 dissociates from activated FGFR4 (Rattus norvegicus)
phospho-p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK2 (TRKB) (Rattus norvegicus)
Activated NTRK2 signals through PLCG1 (Rattus norvegicus)
Activated PCLG1 dissociates from NTRK2 (Rattus norvegicus)
phospho-p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
Signaling by NTRK3 (TRKC) (Rattus norvegicus)
Activated NTRK3 signals through PLCG1 (Rattus norvegicus)
Activated PCLG1 dissociates from NTRK3 (Rattus norvegicus)
phospho-p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
Signaling by PDGF (Rattus norvegicus)
Downstream signal transduction (Rattus norvegicus)
Activated PLC gamma dissociates from the PDGF receptor (Rattus norvegicus)
phospho-p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFR2 mediated cell proliferation (Rattus norvegicus)
PLCG1 disassociates from VEGFR2 and translocate to PM (Rattus norvegicus)
phospho-p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P10686 Plcg1
Gene Names
Plcg1
Chain
initiator methionine:, chain:2-1290
Reference Genes
BioGPS Gene:25738 Plcg1
KEGG Gene (Rattus norvegicus):25738 Plcg1
Monarch:25738 Plcg1
NCBI Gene:25738 Plcg1
UCSC:P10686 Plcg1
Reference Transcript
RefSeq:NM_013187.1 Plcg1
Participates
as a component of
Active ALK:p-4Y PLCG1 [plasma membrane] (Rattus norvegicus)
NTF3:p-5Y-NTRK3 homodimer:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Rattus norvegicus)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
activated FGFR2:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
activated FGFR3:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Rattus norvegicus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Rattus norvegicus)
as a member of
p-4Y-PLCG [plasma membrane] (Rattus norvegicus)
p-PLCG [plasma membrane] (Rattus norvegicus)
as an output of
Activated PCLG1 dissociates from NTRK3 (Rattus norvegicus)
Activated PCLG1 dissociates from NTRK2 (Rattus norvegicus)
p-4Y-PLCG1 dissociates from activated FGFR4 (Rattus norvegicus)
p-4Y-PLCG1 dissociates from activated FGFR2 (Rattus norvegicus)
PLCG1 disassociates from VEGFR2 and translocate to PM (Rattus norvegicus)
p-4Y-PLCG1 dissociates from activated FGFR1 (Rattus norvegicus)
p-4Y-PLCG1 dissociates from activated FGFR3 (Rattus norvegicus)
Activated PLC gamma dissociates from the PDGF receptor (Rattus norvegicus)
Active PLC-gamma1 dissociates from EGFR (Rattus norvegicus)
Other forms of this molecule
p-4Y-Plcg1 [plasma membrane]
phospho-p-Y771,Y783-PLCG1 [plasma membrane]
phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol]
p-Plcg1 [plasma membrane]
Plcg1 [plasma membrane]
PLCG1 [plasma membrane]
PLCG1 [cytosol]
Inferred From
p-4Y-PLCG1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 472
Coordinate
472
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 771
Coordinate
771
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 783
Coordinate
783
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1253
Coordinate
1253
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_037319.1
ZINC target
P10686
PRO
P10686
RGD
3347
PDB
6PBC
,
3GQI
,
1YWP
,
7T8T
,
5EG3
,
4K44
,
1YWO
,
4K45
,
2FJL
,
1Y0M
,
7Z3J
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11362 FGFR1
9
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
FGFR1 [plasma membrane]
(R-HSA-9756433)
0.611
4
UniProt:Q8CGU4 Agap2
1
PIKE-L_RAT [cytosol]
(R-RNO-622356)
0.602
4
UniProt:Q63537
1
Syn2 [clathrin-sculpted monoamine transport vesicle membrane]
(R-RNO-380579)
0.602
5
UniProt:Q08881 ITK
3
p-Y180,Y512-ITK [cytosol]
(R-HSA-2685616)
p-Y512-ITK [cytosol]
(R-HSA-422519)
ITK [cytosol]
(R-HSA-202319)
0.59
2
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.556
4
UniProt:Q9ES52 Inpp5d
3
p-Y-Inpp5d [cytosol]
(R-MMU-9680732)
Inpp5d [cytosol]
(R-MMU-9680650)
Inpp5d [cytosol]
(R-MMU-197940)
0.524
3
UniProt:Q13507 TRPC3
1
TRPC3(1-848) [plasma membrane]
(R-HSA-426172)
0.508
2
UniProt:Q62120 Jak2
11
phospho-p-Y1007,Y1008-JAK2 [cytosol]
(R-MMU-9005327)
p-Jak2 [cytosol]
(R-MMU-8950633)
phospho-p-JAK2 [cytosol]
(R-MMU-210621)
phospho-p-Y813-JAK2 [cytosol]
(R-MMU-997248)
JAK2 [endosome lumen]
(R-MMU-2002372)
JAK2 [cytosol]
(R-MMU-210620)
phospho-p-Y1007-JAK2 [cytosol]
(R-MMU-873799)
Jak2 [cytosol]
(R-MMU-205743)
phospho-p-12Y-JAK2 [cytosol]
(R-MMU-2586516)
p-Y1007-Jak2 [cytosol]
(R-MMU-997296)
p-12Y-Jak2 [cytosol]
(R-MMU-2586515)
0.463
3
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