Reactome | Bdnf [extracellular region]

Bdnf [extracellular region]

Stable Identifier

R-RNO-167028

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

extracellular region

Synonyms

BDNF, P23363

Locations in the PathwayBrowser

Expand all

Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by NTRKs (Rattus norvegicus)
    - Signaling by NTRK2 (TRKB) (Rattus norvegicus)
      - Activated NTRK2 signals through FRS2 and FRS3 (Rattus norvegicus)
        
        Activated NTRK2 binds FRS2 (Rattus norvegicus)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 [plasma membrane] (Rattus norvegicus)
        
        BDNF homodimer [extracellular region] (Rattus norvegicus)
        
        Bdnf [extracellular region] (Rattus norvegicus)
        
        BDNF,NTF4:p-5Y-NTRK2:FRS2 [plasma membrane] (Rattus norvegicus)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 [plasma membrane] (Rattus norvegicus)
        
        BDNF homodimer [extracellular region] (Rattus norvegicus)
        
        Bdnf [extracellular region] (Rattus norvegicus)
        
        NTRK2-phosphorylated FRS2 binds GRB2 (Rattus norvegicus)
        
        BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Rattus norvegicus)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 [plasma membrane] (Rattus norvegicus)
        
        BDNF homodimer [extracellular region] (Rattus norvegicus)
        
        Bdnf [extracellular region] (Rattus norvegicus)
        
        BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane] (Rattus norvegicus)
        
        BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Rattus norvegicus)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 [plasma membrane] (Rattus norvegicus)
        
        BDNF homodimer [extracellular region] (Rattus norvegicus)
        
        Bdnf [extracellular region] (Rattus norvegicus)
      - Activated NTRK2 signals through FYN (Rattus norvegicus)
        
        NTRK2 activates RAC1 (Rattus norvegicus)
        
        DOCK3 activates RAC1 (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:DOCK3 [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1 [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 [plasma membrane] (Rattus norvegicus)
        
        BDNF homodimer [extracellular region] (Rattus norvegicus)
        
        Bdnf [extracellular region] (Rattus norvegicus)
      - Activated NTRK2 signals through PLCG1 (Rattus norvegicus)
        
        Activated PCLG1 dissociates from NTRK2 (Rattus norvegicus)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 [plasma membrane] (Rattus norvegicus)
        
        BDNF homodimer [extracellular region] (Rattus norvegicus)
        
        Bdnf [extracellular region] (Rattus norvegicus)
        
        BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Rattus norvegicus)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Rattus norvegicus)
        
        BDNF:p-5Y-NTRK2 [plasma membrane] (Rattus norvegicus)
        
        BDNF homodimer [extracellular region] (Rattus norvegicus)
        
        Bdnf [extracellular region] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P23363 Bdnf

Gene Names

Bdnf

Chain

signal peptide:1-18, chain:19-249, propeptide:19-130, chain:131-249

Reference Genes

BioGPS Gene:24225 Bdnf

ENSEMBL:ENSRNOG00000047466.3 Bdnf

ENSEMBL:ENSRNOG00055023387 Bdnf

ENSEMBL:ENSRNOG00060001681 Bdnf

ENSEMBL:ENSRNOG00065016064 Bdnf

KEGG Gene (Rattus norvegicus):24225 Bdnf

Monarch:24225 Bdnf

NCBI Gene:24225 Bdnf

Reference Transcript

Other Identifiers

10852620

1368677_at

1368678_at

24225

5713732

5870970

6129942

6172103

6199817

6465105

6565868

6622801

6630747

6640186

6671766

6695100

6700338

A_44_P219026

A_44_P437896

D10938exon_s_at

GO:0005102

ILMN_1360447

PH_rn_0011324

S71201mRNA_at

X67108_at

rc_AI030286_s_at

Participates

as a component of

BDNF homodimer [extracellular region] (Rattus norvegicus)

Other forms of this molecule

Bdnf [extracellular region]

Inferred From

BDNF [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001257566.1, NP_001257564.1, NP_001257567.1, NP_001257562.1, NP_001257560.1, NP_001257565.1, NP_001257559.1, NP_001257563.1, NP_001257561.1, NP_036645.2

Ensembl

ENSRNOT00000089233, ENSRNOT00000090445, ENSRNOP00000073265, ENSRNOP00000074338, ENSRNOT00000083289, ENSRNOT00000080190, ENSRNOP00000072315, ENSRNOP00000075479, ENSRNOP00000073685, ENSRNOT00000078543, ENSRNOG00000047466, ENSRNOT00000077703, ENSRNOP00000072849

PRO

P23363

RGD

2202