Phosphorylated HSL dimer translocates from the cytosol to the lipid particle

Stable Identifier
R-RNO-163597
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, lipid droplet
ReviewStatus
5/5
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Phosphorylated HSL dimer translocates from the cytosol to the lipid particle
In primary adipocytes from young rats and in adipocytes derived from 3T3-L1 cells in vitro, phosphorylated hormone-sensitive lipase translocates from the cytosol to the surfaces of lipid particles following the phosphorylation of perilipin (Clifford et al. 2000; Su et al. 2003; Sztalryd et al. 2003)

The human reaction is inferred from the well-studied rat one.

Literature References
PubMed ID Title Journal Year
10671541 Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes

Yeaman, SJ, Londos, C, Clifford, GM, Vernon, RG, Kraemer, FB

J Biol Chem 2000
Participants
Input
Output
Orthologous Events
Phosphorylated HSL dimer translocates from the cytosol to the lipid particle (Homo sapiens)
Authored
D'Eustachio, P  (2005-05-02)
Created
D'Eustachio, P  (2005-05-02)
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