cholesterol ester + H2O -> cholesterol + fatty acid

Stable Identifier
R-RNO-163407
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, lipid droplet
ReviewStatus
5/5
General
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cholesterol ester + H2O -> cholesterol + fatty acid
Activated rat HSL hydrolyzes cholesterol ester to yield cholesterol + fatty acid (Fredrikson et al. 1981). The human reaction has not been studied in detail, and is inferred from the well-characterized rat one.
Literature References
PubMed ID Title Journal Year
7240206 Hormone-sensitive lipase of rat adipose tissue. Purification and some properties.

Stralfors, P, Belfrage, P, Nilsson, NO, Fredrikson, G

J Biol Chem 1981
Participants
Input
Output
Catalyst Activity

lipase activity of phosphorylated HSL dimer:FABPA complex [lipid droplet]

Physical Entity
phosphorylated HSL dimer:FABPA complex [lipid droplet] (Rattus norvegicus)
Activity
lipase activity (GO:0016298)
Orthologous Events
cholesterol ester + H2O -> cholesterol + fatty acid (Homo sapiens)
Authored
D'Eustachio, P  (2005-05-02)
Created
D'Eustachio, P  (2005-05-02)
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