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P-TEFb complex [nucleoplasm]
Stable Identifier
R-RNO-112431
Type
Complex
Species
Rattus norvegicus
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
TP53 Regulates Transcription of DNA Repair Genes (Rattus norvegicus)
CCNK:CDK12 binds RNA Pol II at DNA repair genes (Rattus norvegicus)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Rattus norvegicus)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Rattus norvegicus)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Rattus norvegicus)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Rattus norvegicus)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Rattus norvegicus)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Rattus norvegicus)
CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Rattus norvegicus)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Rattus norvegicus)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Rattus norvegicus)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Rattus norvegicus)
CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
RNA Polymerase II Pre-transcription Events (Rattus norvegicus)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Rattus norvegicus)
Paused processive elongation complex [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Abortive termination of elongation after arrest (Rattus norvegicus)
Aborted elongation complex after arrest [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Elongating transcript encounters a lesion in the template (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Formation of P-TEFb complex (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Resumption of elongation after recovery from pausing (Rattus norvegicus)
Paused processive elongation complex [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
TFIIS-mediated recovery of elongation from arrest (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
RNA Polymerase II Transcription Elongation (Rattus norvegicus)
Addition of nucleotides leads to transcript elongation (Rattus norvegicus)
Elongation complex [nucleoplasm] (Rattus norvegicus)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Formation of RNA Pol II elongation complex (Rattus norvegicus)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Rattus norvegicus)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Recruitment of elongation factors to form elongation complex (Rattus norvegicus)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Elongation complex [nucleoplasm] (Rattus norvegicus)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Pol II elongation complex moves on the template as transcript elongates (Rattus norvegicus)
Elongation complex prior to separation [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Separation of elongating transcript from template (Rattus norvegicus)
Elongation complex prior to separation [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
RNA polymerase II transcribes snRNA genes (Rattus norvegicus)
CBCAP complex binds 7-methylguanosine cap of snRNA (Rattus norvegicus)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Rattus norvegicus)
RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Rattus norvegicus)
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Integrator complex processes the 3' end of snRNA (Rattus norvegicus)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Pre-snRNA is elongated and capped with 7-methylguanosine (Rattus norvegicus)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Rattus norvegicus)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Rattus norvegicus)
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Rattus norvegicus)
RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by TGFB family members (Rattus norvegicus)
Signaling by TGF-beta Receptor Complex (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Rattus norvegicus)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Rattus norvegicus)
CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Rattus norvegicus)
P-TEFb complex [nucleoplasm] (Rattus norvegicus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
CCNT1,CCNT2,CCNK [nucleoplasm]
(Rattus norvegicus)
CDK9 [nucleoplasm]
(Rattus norvegicus)
Participates
as an output of
Elongating transcript encounters a lesion in the template (Rattus norvegicus)
Formation of P-TEFb complex (Rattus norvegicus)
as an input of
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Rattus norvegicus)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Rattus norvegicus)
as a component of
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Rattus norvegicus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Rattus norvegicus)
Aborted elongation complex after arrest [nucleoplasm] (Rattus norvegicus)
Paused processive elongation complex [nucleoplasm] (Rattus norvegicus)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Rattus norvegicus)
Elongation complex prior to separation [nucleoplasm] (Rattus norvegicus)
Processive elongation complex [nucleoplasm] (Rattus norvegicus)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Rattus norvegicus)
CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Rattus norvegicus)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Rattus norvegicus)
as a member of
CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Rattus norvegicus)
Inferred From
P-TEFb complex [nucleoplasm]
(Homo sapiens)
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