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IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane]
Stable Identifier
R-RNO-1112570
Type
Complex
Species
Rattus norvegicus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-6 family signaling (Rattus norvegicus)
Interleukin-6 signaling (Rattus norvegicus)
IL6ST is tyrosine phosphorylated (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
PTPN11 binds CBL (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
PTPN11 binds p-Y759-IL6ST (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
PTPN11 is phosphorylated (Rattus norvegicus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Phosphorylated STATs are released (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
SOCS3 binds IL6ST (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Serine phosphorylation of STATs (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF-independent MAPK1/3 activation (Rattus norvegicus)
MAPK1 (ERK2) activation (Rattus norvegicus)
MAP2K2 binds MAPK1 (Rattus norvegicus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
MAPK3 (ERK1) activation (Rattus norvegicus)
MAP2K1 binds MAPK3 (Rattus norvegicus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Rattus norvegicus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
IL6:IL6R-2 [extracellular region]
(Rattus norvegicus)
Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane]
(Rattus norvegicus)
Participates
as a member of
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Rattus norvegicus)
Inferred From
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane]
(Homo sapiens)
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