Reactome | RPL27A [cytosol]

RPL27A [cytosol]

Stable Identifier

R-PFA-72442

Type

Protein [EntityWithAccessionedSequence]

Species

Plasmodium falciparum

Compartment

cytosol

Synonyms

C6KT23

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Plasmodium falciparum)

- Nonsense-Mediated Decay (NMD) (Plasmodium falciparum)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Plasmodium falciparum)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Plasmodium falciparum)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Plasmodium falciparum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Plasmodium falciparum)
        
        80S ribosome [cytosol] (Plasmodium falciparum)
        
        60S ribosomal complex [cytosol] (Plasmodium falciparum)
        
        RPL27A [cytosol] (Plasmodium falciparum)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Plasmodium falciparum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Plasmodium falciparum)
        
        80S ribosome [cytosol] (Plasmodium falciparum)
        
        60S ribosomal complex [cytosol] (Plasmodium falciparum)
        
        RPL27A [cytosol] (Plasmodium falciparum)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Plasmodium falciparum)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Plasmodium falciparum)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Plasmodium falciparum)
        
        80S ribosome [cytosol] (Plasmodium falciparum)
        
        60S ribosomal complex [cytosol] (Plasmodium falciparum)
        
        RPL27A [cytosol] (Plasmodium falciparum)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Plasmodium falciparum)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Plasmodium falciparum)
        
        80S ribosome [cytosol] (Plasmodium falciparum)
        
        60S ribosomal complex [cytosol] (Plasmodium falciparum)
        
        RPL27A [cytosol] (Plasmodium falciparum)

External Reference Information

External Reference

UniProt:C6KT23

Reference Genes

BioGPS Gene:3885802

ENSEMBL:PF3D7_0618300

KEGG Gene (Plasmodium falciparum):PF3D7_0618300

Monarch:3885802

NCBI Gene:3885802

PlasmoDB:PF3D7_0618300

Reference Transcript

RefSeq:XM_961075.1

Participates

as a component of

Other forms of this molecule

3OHH39-RPL27A [nucleoplasm]

RPL27A [nucleoplasm]

Inferred From

RPL27A [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_966168.1

PDB

3JBN, 3JBP, 5UMD, 3JBO, 3J79