Reactome | FEN1 [nucleoplasm]

FEN1 [nucleoplasm]

Stable Identifier

R-PFA-54745

Type

Protein [EntityWithAccessionedSequence]

Species

Plasmodium falciparum

Compartment

nucleoplasm

Synonyms

Q7K734

Locations in the PathwayBrowser

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Cell Cycle (Plasmodium falciparum)

- Cell Cycle, Mitotic (Plasmodium falciparum)
  - S Phase (Plasmodium falciparum)
    - Synthesis of DNA (Plasmodium falciparum)
      - DNA strand elongation (Plasmodium falciparum)
        
        Lagging Strand Synthesis (Plasmodium falciparum)
        
        Processive synthesis on the lagging strand (Plasmodium falciparum)
        
        Removal of the Flap Intermediate (Plasmodium falciparum)
        
        Removal of remaining Flap (Plasmodium falciparum)
        
        FEN1 [nucleoplasm] (Plasmodium falciparum)

DNA Repair (Plasmodium falciparum)

- Base Excision Repair (Plasmodium falciparum)
  - Resolution of Abasic Sites (AP sites) (Plasmodium falciparum)
    - Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Plasmodium falciparum)
      - PCNA-Dependent Long Patch Base Excision Repair (Plasmodium falciparum)
        
        POLD,POLE-mediated DNA strand displacement synthesis (Plasmodium falciparum)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Plasmodium falciparum)
        
        FEN1 [nucleoplasm] (Plasmodium falciparum)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Plasmodium falciparum)
        
        FEN1 [nucleoplasm] (Plasmodium falciparum)

DNA Replication (Plasmodium falciparum)

- Synthesis of DNA (Plasmodium falciparum)
  - DNA strand elongation (Plasmodium falciparum)
    - Lagging Strand Synthesis (Plasmodium falciparum)
      - Processive synthesis on the lagging strand (Plasmodium falciparum)
        
        Removal of the Flap Intermediate (Plasmodium falciparum)
        
        Removal of remaining Flap (Plasmodium falciparum)
        
        FEN1 [nucleoplasm] (Plasmodium falciparum)

External Reference Information

External Reference

UniProt:Q7K734

Reference Genes

BioGPS Gene:812356

ENSEMBL:PF3D7_0408500

KEGG Gene (Plasmodium falciparum 3D7):PF3D7_0408500

Monarch:812356

NCBI Gene:812356

PlasmoDB:PF3D7_0408500

Reference Transcript

RefSeq:XM_001351363.1

Participates

as a component of

Inferred From

FEN1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_001351399.1

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