Proteolytic PAK-2p34 fragment translocates to the nucleus

Stable Identifier
R-OCU-266151
Type
Reaction [transition]
Species
Oryctolagus cuniculus
Compartment
General
SVG |   | PPTX  | SBGN
Proteolytic PAK-2p34 fragment translocates to the nucleus

The subcellular localization of PAK-2 is controlled by nuclear localization and nuclear export signal motifs (Jakobi et al.,2003). The regulatory domain contains a nuclear export signal motif that prevents the nuclear accumulation of full-length PAK-2. The activating proteolytic cleavage disrupts the nuclear export signal in PAK-2 and removes most its regulatory domain. The resulting activated PAK-2p34 fragment contains a nuclear localization signal and translocates to and is retained in the nucleus (Jakobi et al.,2003).

Literature References
PubMed ID Title Journal Year
12853446 Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation

Jakobi, R, McCarthy, CC, Koeppel, MA, Stringer, DK

J Biol Chem 2003
Participants
Orthologous Events
Authored
Reviewed
Created