Trim28 binds Zfp809 in Zfp809:MoMLV

Stable Identifier
R-NUL-9843614
Type
Reaction [binding]
Species
Moloney murine leukemia virus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Trim28 binds Zfp809 in Zfp809:MoMLV
In mouse embryonic stem cells, the KRAB-ZFP Zfp809 binds the primer binding site of the Moloney murine leukemia provirus and other retroelements and recruits TRIM28 (also called KAP1) (Wolf and Goff 2009). Trim28 exists as dimers that can form higher order oligomers (Sun et al. 2019).
Literature References
PubMed ID Title Journal Year
31078555 A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family

Turelli, P, Keown, JR, Raclot, C, Black, MM, Demarais, N, Trono, D, Sun, Y, Goldstone, DC

J Mol Biol 2019
19270682 Embryonic stem cells use ZFP809 to silence retroviral DNAs

Wolf, D, Goff, SP

Nature 2009
Participants
Input
Output
Orthologous Events
TRIM28 (KAP1) binds KRAB-ZFP in KRAB-ZFP:retroelement chromatin (Homo sapiens)
Authored
May, B  (2023-09-08)
Reviewed
Bourc'his, D  (2024-05-14)
Fernandes, LP  (2024-05-14)
Created
May, B  (2023-09-08)
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