Active ALK binds Frs2

Stable Identifier
R-NUL-9700145
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Active ALK binds Frs2
Rat Frs2 co-immunoprecipitates with human ALK when co-expressed in HEK203 cells. Interaction is dependent on the tyrosine kinase activity of ALK, although a precise binding site for FRS2 has not been identified (Degoutin et al, 2007).
Literature References
PubMed ID Title Journal Year
17274988 ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation

Vigny, M, Degoutin, J, Gouzi, JY

FEBS Lett. 2007
Participants
Input
Output
Orthologous Events
Active ALK binds FRS2 (Homo sapiens)
Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2020-09-14)
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