Defective Mutyh mutants do not cleave adenine mispaired with 8-oxoguanine

Stable Identifier
R-NUL-9606338
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Defective Mutyh mutants do not cleave adenine mispaired with 8-oxoguanine

Mutant variants of mouse Mutyh, Mutyh G257E and Mutyh A341V show impaired DNA glycosylase activity. These mutants correspond to MUTYH G272E and MUTYH A359V mutants, respectively, detect in Japanese adenomatous polyposis patients (Yanaru-Fujisawa et al. 2008).

Literature References
PubMed ID Title Journal Year
18422726 Genomic and functional analyses of MUTYH in Japanese patients with adenomatous polyposis

Yanaru-Fujisawa, R, Matsumoto, T, Ushijima, Y, Esaki, M, Hirahashi, M, Gushima, M, Yao, T, Nakabeppu, Y, Iida, M

Clin. Genet. 2008
Participants
Normal reaction
Functional status

Loss of function of Mutyh G257E,Mutyh A341V:(OGUA:Ade)-dsDNA [nucleoplasm]

Status
Orthologous Events
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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