Proteasome degrades ubiquitinated mouse NICD4

Stable Identifier
R-NUL-9604648
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Proteasome degrades ubiquitinated mouse NICD4
Ubiquitination of mouse NICD4 (Notch4 intracellular domain fragment), expressed in human cell line BOSC23, mediated by human FBXW7, targets NICD4 for proteasome-mediated degradation (Wu et al. 2001).
Literature References
PubMed ID Title Journal Year
11585921 SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

Das, I, Wu, G, Deshaies, RJ, Kitajewski, J, Li, J, Pauley, A, Chui, I, Gurney, M, Lyapina, S

Mol Cell Biol 2001
Participants
Input
Output
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

Physical Entity
26S proteasome [nucleoplasm] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-04)
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