Proteasome degrades ubiquitinated mouse NICD4

Stable Identifier
R-NUL-9604648
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Proteasome degrades ubiquitinated mouse NICD4

Ubiquitination of mouse NICD4 (Notch4 intracellular domain fragment), expressed in human cell line BOSC23, mediated by human FBXW7, targets NICD4 for proteasome-mediated degradation (Wu et al. 2001).

Literature References
PubMed ID Title Journal Year
11585921 SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

Wu, G, Lyapina, S, Das, I, Li, J, Gurney, M, Pauley, A, Chui, I, Deshaies, RJ, Kitajewski, J

Mol Cell Biol 2001
Participants
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
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