FLT4 gene expression is stimulated by Notch4

Stable Identifier
R-NUL-9604519
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
General
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PNG
Low
Medium
High
 | PPTX  | SBGN
FLT4 gene expression is stimulated by Notch4
Recombinant mouse Notch4 intracellular domain fragment (NICD4) stimulates transcription from the promoter of the human FLT4 (VEGFR) gene (Shawber et al. 2007).
Literature References
PubMed ID Title Journal Year
17948123 Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

Shawber, CJ, Funahashi, Y, Francisco, E, Vorontchikhina, M, Kitamura, Y, Stowell, SA, Borisenko, V, Feirt, N, Podgrabinska, S, Shiraishi, K, Chawengsaksophak, K, Rossant, J, Accili, D, Skobe, M, Kitajewski, J

J. Clin. Invest. 2007
Participants
Input
Output
This event is regulated
Positively by
Regulator
Notch4 coactivator complex [nucleoplasm] (Homo sapiens)
Orthologous Events
FLT4 gene expression is stimulated by NOTCH4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-04)
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