Gamma-secretase cleaves Notch4

Stable Identifier
R-NUL-9604300
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Gamma-secretase cleaves Notch4
Enzymatic activity of the human gamma-secretase complex is need for the release of the cytoplasmic fragment (NICD4) from the membrane-bound recombinant mouse Notch4-derived int-3 oncogene expressed in human cells (Das et al. 2004).
Literature References
PubMed ID Title Journal Year
15123653 Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function

Das, I, Craig, C, Kim, TW, Kutok, JL, Aster, JC, Kitajewski, J, Weng, AP, Jung, KM, Funahashi, Y, Byers, R

J. Biol. Chem. 2004
Participants
Input
Output
Catalyst Activity

aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]

Physical Entity
gamma-secretase complex [plasma membrane] (Homo sapiens)
Activity
aspartic-type endopeptidase activity (GO:0004190)
Orthologous Events
Gamma-secretase cleaves NOTCH4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-02)
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