Gamma-secretase cleaves Notch4

Stable Identifier
R-NUL-9604300
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Gamma-secretase cleaves Notch4

Enzymatic activity of the human gamma-secretase complex is need for the release of the cytoplasmic fragment (NICD4) from the membrane-bound recombinant mouse Notch4-derived int-3 oncogene expressed in human cells (Das et al. 2004).

Literature References
PubMed ID Title Journal Year
15123653 Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function

Das, I, Craig, C, Funahashi, Y, Jung, KM, Kim, TW, Byers, R, Weng, AP, Kutok, JL, Aster, JC, Kitajewski, J

J. Biol. Chem. 2004
Participants
Catalyst Activity
Catalyst Activity
Title
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created