BDNF- or NTF4-activated Ntrk2 binds Shc1

Stable Identifier
R-NUL-9030473
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
BDNF- or NTF4-activated Ntrk2 binds Shc1
Mouse Ntrk2, activated by recombinant human BDNF or NTF4 (NT-4), binds Shc1 isoforms p52 (Shc-1) and p47 (Shc1-3) (Minichiello et al. 1998).
Literature References
PubMed ID Title Journal Year
9728915 Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses

Minichiello, L, Casagranda, F, Tatche, RS, Stucky, CL, Postigo, A, Lewin, GR, Davies, AM, Klein, R

Neuron 1998
Participants
Input
Output
Orthologous Events
p-Y516 of p-5Y-NTRK2 recruits SHC1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Antila, H  (2018-02-13)
Castrén, E  (2018-02-13)
Created
Orlic-Milacic, M  (2017-11-28)
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