NTF3-bound Ntrk2 dimers trans-autophosphorylate

Stable Identifier
R-NUL-9030397
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NTF3-bound Ntrk2 dimers trans-autophosphorylate
In response to stimulation with a recombinant human NTF3 (NT-3), a recombinant rat Ntrk2 (Trkb) trans-autophosphotylates at tyrosine residue Y816 (Y785 in mature protein) and in the region containing tyrosine residues Y701, Y705 and Y706 (residues Y670, Y674 and Y675 in mature rat Ntrk2) (Middlemas et al. 1994). Phosphorylation of rat Ntrk2 at Y515 (Y484 in mature protein) has not been examined but is assumed.
Literature References
PubMed ID Title Journal Year
8106527 Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor

Middlemas, DS, Hunter, T, Meisenhelder, J

J. Biol. Chem. 1994
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of NTF3:Ntrk2 homodimer [plasma membrane]

Physical Entity
NTF3:Ntrk2 homodimer [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
NTF3-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-11-27)
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