BDNF-bound Ntrk2 dimers trans-autophosphorylate

Stable Identifier
R-NUL-9030372
Type
Reaction
Species
Homo sapiens
Compartment
General
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BDNF-bound Ntrk2 dimers trans-autophosphorylate

A recombinant human BDNF-induced dimerization of the rat receptor tyrosine kinase Ntrk2 (TrkB) leads to trans-autophosphorylation of Ntrk2 on five evolutionarily conserved tyrosine residues in the cytoplasmic tail of Ntrk2. Residues Y484, Y670, Y674, Y675 and Y785 of mature rat Ntrk2 (Y515, Y701, Y705, Y706 and Y816 of full-length rat Ntrk2) correspond to residues Y516, Y702, Y706, Y707 and Y817 of human NTRK2 (Guiton et al. 1994, McCarty and Feinstein 1999).

Literature References
PubMed ID Title Journal Year
7982951 Identification of in vivo brain-derived neurotrophic factor-stimulated autophosphorylation sites on the TrkB receptor tyrosine kinase by site-directed mutagenesis

Guiton, M, Gunn-Moore, FJ, Stitt, TN, Yancopoulos, GD, Tavaré, JM

J. Biol. Chem. 1994
10533983 The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL

McCarty, JH, Feinstein, SC

J. Recept. Signal Transduct. Res. 1999
Participants
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of BDNF:Ntrk2 homodimer [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created