Carboxypeptidase E (rat Carboxypeptidase H) cleaves Insulin(25-56) to yield Insulin(25-54)

Stable Identifier
R-NUL-9023166
Type
Reaction [transition]
Species
Homo sapiens
Compartment
secretory granule membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Carboxypeptidase E (rat Carboxypeptidase H) cleaves Insulin(25-56) to yield Insulin(25-54)
Carboxypeptidase E (also called Carboxypeptidase H) purified from rat beta cells cleaves the C-terminal two amino acid residues (ariginine-56 and arginine-55) from the B chain derived from human proinsulin (Davidson and Hutton 1987).
Literature References
Participants
Input
Output
Catalyst Activity

metallocarboxypeptidase activity of Cpe:Zn2+ [secretory granule membrane]

Physical Entity
Cpe:Zn2+ [secretory granule membrane] (Rattus norvegicus)
Activity
metallocarboxypeptidase activity (GO:0004181)
Orthologous Events
Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) (Homo sapiens)
Authored
May, B  (2017-09-25)
Reviewed
Gillespie, ME  (2008-12-02)
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Created
May, B  (2017-09-27)
Cite Us!