EBAX-1 ubiquitinates SAX-3

Stable Identifier
R-NUL-9011317
Type
Reaction [omitted]
Species
Caenorhabditis elegans
Compartment
cytosol
ReviewStatus
5/5
General
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EBAX-1 ubiquitinates SAX-3
C. elegans protein EBAX-1 (orthologue of ZSWIM8) promotes ubiquitinates of C. elegans SAX-3 (orthologue of ROBO3.1) when recombinant C. elegans proteins are expressed in human embryonic kidney cell line HEK293T (Wang et al. 2013).
Literature References
PubMed ID Title Journal Year
24012004 The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons

Guo, X, Jin, Y, Boxem, M, Hou, Y, Wang, Z, van der Voet, M, Dixon, JE, Chisholm, AD

Neuron 2013
Participants
Input
Output
Catalyst Activity

ubiquitin protein ligase activity of EBAX-1 [cytosol]

Physical Entity
EBAX-1 [cytosol] (Caenorhabditis elegans)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
ZSWIM8 ubiquitinates ROBO3.1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-23)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-06-29)
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