TTCP hydrolyzes the terminal L-Tyr residue from alpha-tubulin

Stable Identifier
R-NUL-8955728
Type
Reaction [transition]
Species
Bos taurus
Compartment
General
SVG |   | PPTX  | SBGN
TTCP hydrolyzes the terminal L-Tyr residue from alpha-tubulin

TTCP (tubulinyl-tyrosine carboxypeptidase) hydrolyzes the terminal L-Tyr residue from the alpha-tubulin subunit of an alpha tubulin:beta tubulin dimer to yield delY-alpha tubulin and L-tyrosine (L-Tyr). Although TTCP enzyme has not been purified from any species, studies of material partially purified from chicken brain have allowed its activity to be defined and distinguished from those of widely expressed carboxypeptidases with broader substrate specificities (Argarana et al. 1980). These studies were carried out with microtubulues and alpha-beta tubulin dimers from brain; here a bovine alpha-beta tubulin dimer (TUBA1B:TUBB4A) has been annotated as the substrate although all alpha-tubulins with a carboxyterminal tyrosine residue are thought to serve as substrates.

Literature References
PubMed ID Title Journal Year
7452228 Tubulinyl-tyrosine carboxypeptidase from chicken brain: properties and partial purification

Argarana, CE, Barra, HS, Caputto, R

J. Neurochem. 1980
Participants
Event Information
Catalyst Activity
Catalyst Activity
Title
metallocarboxypeptidase activity of TTCP [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created