Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors

Stable Identifier
R-NUL-8853328
Type
Reaction [binding]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors

Mouse FGFT2 IIIa TM has been shown to bind to FGFR2b and c in the presence of FGF1 in vitro, and to inhibit signaling in vivo and in cell culture in an FGF2-dependent manner. Inhibition of FGFR signaling may arise as a result of ligand sequestration and/or through the formation of non-functional heterodimers with full-length receptors (Wheldon et al, 2011).

Literature References
PubMed ID Title Journal Year
21355848 Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model

Wheldon, LM, Khodabukus, N, Patey, SJ, Smith, TG, Heath, JK, Hajihosseini, MK

Biochem. J. 2011
Participants
Orthologous Events
Disease
Name Identifier Synonyms
acrocephalosyndactylia 12960 Apert syndrome
Authored
Reviewed
Created