Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors

Stable Identifier
R-NUL-8853328
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors
Mouse FGFT2 IIIa TM has been shown to bind to FGFR2b and c in the presence of FGF1 in vitro, and to inhibit signaling in vivo and in cell culture in an FGF2-dependent manner. Inhibition of FGFR signaling may arise as a result of ligand sequestration and/or through the formation of non-functional heterodimers with full-length receptors (Wheldon et al, 2011).
Literature References
PubMed ID Title Journal Year
21355848 Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model

Hajihosseini, MK, Khodabukus, N, Heath, JK, Smith, TG, Patey, SJ, Wheldon, LM

Biochem. J. 2011
Participants
Input
Output
Orthologous Events
FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling (Homo sapiens)
Disease
Name Identifier Synonyms
acrocephalosyndactylia DOID:12960 Apert syndrome
Authored
Rothfels, K  (2016-01-09)
Reviewed
Grose, RP  (2016-01-25)
Created
Rothfels, K  (2016-01-22)
Cite Us!