Gli2is degraded by the proteasome

Stable Identifier
R-NUL-5610751
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Gli2is degraded by the proteasome

Gli2 is degraded in a proteasome-dependent manner after phosphorylation and ubiquitination (Pan et al, 2006).

Literature References
PubMed ID Title Journal Year
16611981 Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

Pan, Y, Bai, CB, Joyner, AL, Wang, B

Mol. Cell. Biol. 2006
Participants
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created