Translocon (canine) translocates Preprolactin (bovine)

Stable Identifier
R-NUL-445275
Type
Reaction [binding]
Species
Bos taurus
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
General
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PNG
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Translocon (canine) translocates Preprolactin (bovine)
The heterotrimer of SEC61-alpha, SEC61-beta, and SEC61-gamma form a single channel called the translocon that spans the endoplasmic reticulum membrane and is able to transport a nascent peptide from the cytosol to the endoplasmic reticulum lumen. The reaction described here contains proteins from two species (Bos taurus and Canis familiaris) and was demonstrated in vitro. The translocon is part of a larger complex that contains the translocon-associated (TRAP) complex and the oligosaccharyltransferase complex.
Literature References
PubMed ID Title Journal Year
8107851 Evolutionary conservation of components of the protein translocation complex

Sommer, T, Hartmann, E, Jentsch, S, Görlich, D, Prehn, S, Rapoport, TA

Nature 1994
15051734 The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells

Bogert, BA, Lippincott-Schwartz, J, Hegde, RS, Reinhart, GA, Snapp, EL

J Cell Biol 2004
18778738 A single Sec61-complex functions as a protein-conducting channel

Kalies, KU, Hartmann, E, Stokes, V

Biochim Biophys Acta 2008
Participants
Input
Output
Orthologous Events
Signal-containing nascent peptide translocates to endoplasmic reticulum (Homo sapiens)
Authored
May, B  (2009-10-28)
Reviewed
May, B  (2009-10-28)
Created
May, B  (2009-10-29)
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