Activation of Clasp

Stable Identifier
R-NUL-428884
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
General
SVG |   | PPTX  | SBGN
Activation of Clasp

Human CLASP (CLASP1 or CLASP2) acts positively downstream of Drosophila Abl as part of the repellent response initiated by activation of Drosophila Robo1. Activation of CLASP results in inhibition of microtubule polymerization on the side of the growth cone receiving the repulsive signal and consequently the growth cone turns to the opposite side (Wills et al. 2002, Lee et al. 2004, Kalil and Dent 2004).

Literature References
PubMed ID Title Journal Year
12441051 A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding

Wills, Z, Emerson, M, Rusch, J, Bikoff, J, Baum, B, Perrimon, N, Van Vactor, D

Neuron 2002
15207236 The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance

Lee, H, Engel, U, Rusch, J, Scherrer, S, Sheard, K, Van Vactor, D

Neuron 2004
Participants
Orthologous Events
Authored
Reviewed
Created
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