Autophosphorylation of NCAM1 bound Fyn

Stable Identifier
R-NUL-420398
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Autophosphorylation of NCAM1 bound Fyn

The Tyr420 residue located in the activation loop of Fyn is responsible for its enzymatic activity. Once the Tyr531 in its negative regulatory site is dephosphorylated by RPTPalpha, Fyn undergoes autophosphorylation on Tyr420 for its maximum activity.

Literature References
PubMed ID Title Journal Year
9079653 NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn)

Beggs, HE, Baragona, SC, Hemperly, JJ, Maness, PF

J Biol Chem 1997
15623578 RPTPalpha is essential for NCAM-mediated p59fyn activation and neurite elongation

Bodrikov, V, Leshchyns'ka, I, Sytnyk, V, Overvoorde, J, den Hertog, J, Schachner, M

J Cell Biol 2005
Participants
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Fyn [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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