Reactome | ADP is exchanged for ATP in the ADP:CCT/TriC:tubulin complex

ADP is exchanged for ATP in the ADP:CCT/TriC:tubulin complex

Stable Identifier

R-NUL-389973

Type

Reaction [transition]

Species

Mus musculus

Compartment

cytosol

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

ADP is exchanged for ATP in the ADP:CCT/TriC:tubulin complex

The interaction between CCT and unfolded target proteins is thought to occur when CCT is in its ADP-bound state. ADP is then exchanged for ATP in CCT.

Literature References

PubMed ID	Title	Journal	Year
7909354	Facilitated folding of actins and tubulins occurs via a nucleotide-dependent interaction between cytoplasmic chaperonin and distinctive folding intermediates Melki, R, Cowan, NJ	Mol Cell Biol	1994
9153422	Cytoplasmic chaperonin containing TCP-1: structural and functional characterization Williams RC, Jr, Soulié, S, Melki, R, Batelier, G	Biochemistry	1997