sFrp binds Wnt3a and inhibits WNT-FZD binding

Stable Identifier
R-NUL-3772439
Type
Reaction [binding]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
sFrp binds Wnt3a and inhibits WNT-FZD binding

Mouse Wnt3a binds directly with nanomolar affinities to four sFRPs that were tested (mouse sFRP2 and 3 and human sFRP1 and 4), as assessed by surface plasmon resonance. Despite this, only sFRP1 and 2 were able to inhibit Wnt3a signaling in mouse L cells. sFRP2 was also shown to inhibit Wnt3a dependent mesoderm formation in mouse ES cells (Wawrzak et al, 2007).

Literature References
PubMed ID Title Journal Year
17462603 Wnt3a binds to several sFRPs in the nanomolar range

Wawrzak, D, M├ętioui, M, Willems, E, Hendrickx, M, de Genst, E, Leyns, L

Biochem. Biophys. Res. Commun. 2007
Participants
Orthologous Events
Authored
Reviewed
Created
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