MAP3K5 (ASK1) phosphorylates Map2k4(Sek1)

Stable Identifier
R-NUL-3299417
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
MAP3K5 (ASK1) phosphorylates Map2k4(Sek1)
Recombinant human MAP3K5 (ASK1) is needed for phosphorylation of recombinant mouse Map2k4 (Sek1) when both proteins are exogenously expressed in COS7 cells. The direct phosphorylation of Map2k4 by MAP3K5 was demonstrated in vitro, using recombinant human MAP3K5 and recombinant Xenopus Map2k4 (Ichijo et al. 1997).
Literature References
PubMed ID Title Journal Year
8974401 Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

Nishida, E, Irie, K, Ichijo, H, Matsumoto, K, Saitoh, M, ten Dijke, P, Gotoh, Y, Moriguchi, T, Miyazono, K, Takagi, M

Science 1997
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of MAP3K5 [cytosol]

Physical Entity
MAP3K5 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1) (Homo sapiens)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-04-18)
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