Degradation of fibrilin-1 by Elane

Stable Identifier
R-NUL-2514835
Type
Reaction [transition]
Species
Bos taurus
Compartment
extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Degradation of fibrilin-1 by Elane
Fibrillin-1, the major structural component of microfibrils (Kielty et al. 2005), can be degraded by neutrophil elastase (ELANE) (Kielty et al. 1994).
Literature References
PubMed ID Title Journal Year
8076699 Catabolism of intact fibrillin microfibrils by neutrophil elastase, chymotrypsin and trypsin

Kielty, CM, Woolley, DE, Whittaker, SP, Shuttleworth, CA

FEBS Lett. 1994
Participants
Input
Output
Catalyst Activity

serine-type endopeptidase activity of ELANE [extracellular region]

Physical Entity
ELANE [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Fibrillin-1 degradation by ELANE (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-10)
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